Mr. Universe: You can’t stop the signal, Mal.

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Simon: Now River, stay behind the others. If there’s fighting, drop to the floor or run away. It’s okay to leave them to die.
Mal: Doctor. I’m taking your sister under my protection here. If anything happens to her, anything at all, I swear to you — I will get very choked up. Honestly. There could be tears.

The Operative: Do you know what your sin is, Mal?
Mal: Oh hell, I’m a fan of all seven. But right now, I’m gonna have to go with wrath.

Jayne: Shiny! Let’s be bad guys.

The Operative: You’ve done remarkable things, but you’re fighting a war you’ve already lost.
Mal: Yeah, well I’m known for that.