Denny Duquette: I’ve been lying in this bed for close to a year, and I’ve had a lot of time to look back on my life. And the things that I remember best – those are the things I wasn’t supposed to do and I did them anyway. The thing is, life is too damn short to be following these rules.

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Dr. Meredith Grey: Okay here it is. Your choice. It’ s simple. Her or me. And I’m sure she’ s really great. But Derek, I love you, in a really, really big – pretend to like your taste in music, let you eat the last piece of cheesecake, hold a radio over my head outside your window – unfortunate way that makes me hate you, love you. So pick me. Choose me. Love me.

Bring the Pain (season 2, episode 5)

Meredith: If there’s an upside to free falling, it’s the chance you give your friends to catch you.

Dr. Meredith Grey: The key to surviving a surgical internship is denial. We deny that we’re tired, we deny that we’re scared, we deny how badly we want to succeed. And most importantly, we deny that we’re in denial. We only see what we want to see and believe what we want to believe, and it works. We lie to ourselves so much that after a while the lies start to seem like the truth. We deny so much that we can’t recognize the truth right in front of our faces.

Dr. George O’Malley: Modest looks weird on you.

Dr. Meredith Grey: Pain, you just have to ride it out, hope it goes away on its own, hope the wound that caused it heals. There are no solutions, no easy answers, you just breath deep and wait for it to subside. Most of the time pain can be managed but sometimes the pain gets you where you least expect it. Hits way below the belt and doesn’t let up. Pain, you just have to fight through, because the truth is you can’t outrun it and life always makes more.