Dr. Meredith Grey: I want facts and until I get them my pants are staying on.

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Merideth: McSteamy.
George: Merideth.
Merideth: McSteamy! Whoo hoo!
Mark: So is that what you’re calling me now, McSteamy?
Merideth: Yeah, but I don’t think you’re supposed to know that.
Mark: So, how’s my favorite dirty mistress?
Merideth: Haven’t you heard? Now I’m an adulteress whore.

Denny Duquette: I’ve been lying in this bed for close to a year, and I’ve had a lot of time to look back on my life. And the things that I remember best – those are the things I wasn’t supposed to do and I did them anyway. The thing is, life is too damn short to be following these rules.

I’ve heard that it’s possible to grow up – I’ve just never met anyone who’s actually done it. Without parents to defy, we break the rules we make for ourselves. We throw tantrums when things don’t go our way, we whisper secrets with our best friends in the dark, we look for comfort where we can find it, and we hope .. against all logic, against all experience. Like children, we never give up hope.

Dr. Meredith Grey: How do you know when how much is too much? Too much too soon. Too much information. Too much fun. Too much love. Too much to ask… And when is it all just too much to bear?

Dr. George O’Malley: I will never leave you. I will never hurt you. And I will never stop loving you.