Anderson: Never mind that, we found the case! According to “someone,” the murderer has the case, and here we found it, in the hands of our favorite psychopath.
Sherlock Holmes: I’m not a psychopath, Anderson, I’m a high-functioning sociopath. Do your research.

A Study in Pink (season 1, episode 1)

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Stamford: Last thing I heard you were overseas being shot at. So what happened?
Watson: I got shot.

A Study in Pink (season 1, episode 1)

Holmes: They’re killings, serial killings! We’ve got a serial killer on our hands. I love those, there’s always something to look forward to.

A Study in Pink (season 1, episode 1)

Watson: Why didn’t I think of that?
Holmes: Because you’re an idiot. No, no, no, don’t be like that, practically everyone is.

A Study in Pink (season 1, episode 1)

Lestrade: It’s a drugs bust.
Watson: Seriously. This guy, a junkie? Have you met him?
Holmes: John.
Watson: I’m pretty sure you could search this flat all day and you wouldn’t find anything that you could call recreational.

A Study in Pink (season 1, episode 1)

Holmes: What’s wrong?
Watson: I just met a friend of yours.
Holmes: A friend?
Watson: An enemy.
Holmes: Oh. Which one?
Watson: Your arch enemy. According to him.
Holmes: Oh. Did he offer you money to spy on me?
Watson: Yes.
Holmes: Did you take it?
Watson: No.
Holmes: Pity, we could’ve split the fee. Think it over next time.

A Study in Pink (season 1, episode 1)