Watson: What are you doing?
Holmes: Nicotine patch. Helps me think. It’s impossible to sustain a smoking habit in London these days.
Watson: That’s good news for breathing.
Holmes: Ah, breathing. Breathing’s boring.
Watson: Is that three patches?
Holmes: It’s a three-patch problem.

A Study in Pink (season 1, episode 1)

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Sherlock Holmes: Shut up.
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A Study in Pink (season 1, episode 1)

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A Study in Pink (season 1, episode 1)

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A Study in Pink (season 1, episode 1)

Lestrade: It’s a drugs bust.
Watson: Seriously. This guy, a junkie? Have you met him?
Holmes: John.
Watson: I’m pretty sure you could search this flat all day and you wouldn’t find anything that you could call recreational.

A Study in Pink (season 1, episode 1)