Watson: What are you doing?
Holmes: Nicotine patch. Helps me think. It’s impossible to sustain a smoking habit in London these days.
Watson: That’s good news for breathing.
Holmes: Ah, breathing. Breathing’s boring.
Watson: Is that three patches?
Holmes: It’s a three-patch problem.

A Study in Pink (season 1, episode 1)

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Watson: Who are you?
Mycroft: An interested party.
Watson: Interested in Sherlock? Why? I’m guessing you’re not friends.
Mycroft: You’ve met him. How many friends do you imagine he has?

A Study in Pink (season 1, episode 1)

Anderson: So we can read her emails, so what?
Sherlock Holmes: Anderson, don’t talk out loud. You lower the IQ of the entire street.

A Study in Pink (season 1, episode 1)