Themes
It's the most unhappy people who most fear change.
— Mignon McLaughlin

Behind the line May contain spoilers.
Our reading
An editorial interpretation.
The observation places strong resistance to change beside deep unhappiness. Those conditions might seem to pull in opposite directions, since change could alter an unsatisfying situation. The statement draws attention to their coexistence without explaining the cause or promising that any particular change would help.
Context reviewed