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Don't call me irrational. It makes me crazy when you do that.
— Niles · Frasier
Behind the line May contain spoilers.
Our reading
An editorial interpretation.
The speaker protests at being called irrational, then says the accusation makes them crazy. The joke turns on that verbal contradiction: the attempt to defend their reasonableness borrows the very language of losing it, without establishing that the accusation is actually fair.
Context reviewed