Characters
Gay men and straight girls sleeping together… isn’t that one of the signs of the Apocalypse?
— Ted ‧ Queer as Folk

Behind the line May contain spoilers.
Our reading
An editorial interpretation.
The speaker treats gay men and straight women sleeping together as a possible sign of apocalypse. The enormous consequence makes the surprise comic. The joke depends on expectations about sexuality and pairing, turning their apparent disruption into an absurdly exaggerated vision of cosmic disorder.
Context reviewed