Characters
For God's sake, do something. Say something.
— Murray · The Odd Couple

Behind the line May contain spoilers.
Our reading
An editorial interpretation.
The speaker pleads, in exasperation, for the other person to react in some way, whether through action or words. Any response would be better than the frustrating stillness. The repeated demand, 'do something,' then 'say something,' makes the urgency and desperation for a reaction feel sharper.
Context reviewed