Characters
Oh loneliness and cheeseburgers are a deadly combination.
— Comic Book Guy • The Simpsons
Behind the line May contain spoilers.
Our reading
An editorial interpretation.
The speaker declares, with mock gravity, that loneliness and cheeseburgers together are deadly. The joke treats comfort eating as a lethal combination, letting a wry remark quietly carry a real note of sadness about solitude.
Context reviewed